![]() ![]() 8), suggesting that the effect of granulation parameters on tablet dissolution is achieved through their impact on granule porosity. In addition, granule pore diameter showed similar dependence on granulation parameters as tablet dissolution rate ( Fig. Tablet dissolution rate increased with the increase in granule pore diameter (determined by mercury intrusion porosimetry) ( Fig. Higher level of water, impeller speed, or wet massing time resulted in a decrease in dissolution rate. All three wet granulation process parameters affected tablet dissolution in the same direction. Regression analysis showed that all main effects of the three granulation parameters and two-way interactions were statistically significant ( P < 0.05) for the amount of drug dissolved at 30 min. Experimental design batches are shown in Table 3 ( Badawy, Narang, Lamarche, Subramanian, & Varia, 2012). A 2 3 full factorial design with three replicate center points was used to study the effect of these parameters on tablet dissolution at 2 kg scale in a 10-L high-shear granulator using a single batch of drug substance. The results of the screening study identified the following process parameters for the granulation process DOE study (1) water amount, (2) impeller tip speed, and (3) wet massing time. ![]() Thus, it was found that SSG failed to aid the disintegration of mannitol tablets.Ī preliminary screening study was conducted to select wet granulation parameters to be studied in a full factorial DOE study. In addition, increasing the compaction pressure during tablet formation produced mechanically stronger tablet but resulting in relatively higher frictional forces during the ejection stage. It was discovered that the addition of sodium starch glycolate (SSG) super disintegrant negatively affects the mannitol tablet disintegration and mechanical integrity for the compositions tested in this current work. The experiments also measured and calculated the deformation behavior of the binary mannitol-SSG mixture during the uniaxial die compaction process and its friction characteristics during ejection stage. The interactions studied were focused on how the overall binary mixture mannitol-SSG tablet disintegration and mechanical integrity were affected by increasing the amounts of SSG added and the compaction pressures used during tablet formation. This work presents a study on the interactions between a super disintegrant, sodium starch glycolate (SSG) with a mannitol, a tablet sweetener. Fara Wahida Ahmad Hamidi, in Reference Module in Materials Science and Materials Engineering, 2023 Abstract ![]()
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